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- Title
Enantioselective Formation of All-Carbon Quaternary Stereocenters from Indoles and Tertiary Alcohols Bearing A Directing Group.
- Authors
Zhao, Wanxiang; Wang, Zhaobin; Chu, Boyang; Sun, Jianwei
- Abstract
Described is an efficient catalytic asymmetric intermolecular CC bond-formation process to generate acyclic all-carbon quaternary stereocenters. The reactions overcome the unfavorable steric hindrance around reactive centers, and the competitive elimination (E1), to form a range of useful indole products with excellent efficiency and enantioselectivity.
- Subjects
ENANTIOSELECTIVE catalysis; QUATERNARY structure; INDOLE compounds; BUTYL methyl ether; CARBON-carbon bonds; INTERMOLECULAR interactions; ORGANIC synthesis
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 6, p1910
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201405252