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- Title
Perspective on architecture and assembly of membrane contact sites.
- Authors
Hoffmann, Patrick C.; Kukulski, Wanda
- Abstract
Membrane contact sites (MCS) are platforms of physical contact between different organelles. They are formed through interactions involving lipids and proteins, and function in processes such as calcium and lipid exchange, metabolism and organelle biogenesis. In this article, we discuss emerging questions regarding the architecture, organisation and assembly of MCS, such as: What is the contribution of different components to the interaction between organelles? How is the specific composition of different types of membrane contacts sites established and maintained? How are proteins and lipids spatially organised at MCS and how does that influence their function? How dynamic are MCS on the molecular and ultrastructural level? We highlight current state of research and point out experimental approaches that promise to contribute to a spatiomechanistic understanding of MCS functions.
- Subjects
PROTEIN-lipid interactions; ORGANELLE formation; MEMBRANE proteins; ULTRASTRUCTURE (Biology); ENDOPLASMIC reticulum
- Publication
Biology of the Cell (Wiley-Blackwell), 2017, Vol 109, Issue 12, p400
- ISSN
0248-4900
- Publication type
Article
- DOI
10.1111/boc.201700031