We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Thymoma. A clinicopathologic review.
- Authors
Lewis, Jean E.; Wick, Mark R.; Scheithauer, Bernd W.; Bernatz, Philip E.; Taylor, William F.; Lewis, J E; Wick, M R; Scheithauer, B W; Bernatz, P E; Taylor, W F
- Abstract
The clinical and pathologic features of 283 patients with thymoma treated at the Mayo Clinic (147 female and 136 male; ages 16 years to 90 years; mean, 52 years) were examined. Forty-six percent of the patients had myasthenia gravis and 10% had other paraneoplastic phenomena. The tumors were locally invasive at operation in 32%, including 6% with metastasis to lung or pleura. Intrathoracic recurrence was noted postoperatively in 15% of those who had total excision and distant metastasis developed in 3% of patients. Thirteen percent died of their thymomas and 16% died of myasthenia. Overall 5-year survival was 67% and 10-year survival was 53%. Poor prognostic factors included presence of tumor-related symptoms, large tumor size, local invasion or metastasis in initial operation, and predominantly epithelial histologic features. Although true thymomas are composed of cytologically benign elements, they show a propensity for local invasion and intrathoracic recurrence. They rarely metastasize outside the thorax.
- Publication
Cancer (0008543X), 1987, Vol 60, Issue 11, p2727
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19871201)60:11<2727::AID-CNCR2820601125>3.0.CO;2-D