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- Title
Hypercoagulable state induced by cytostatic drugs in stage II breast cancer patients.
- Authors
Canobbio, Luciano; Fassio, Tiziana; Ardizzoni, Andrea; Bruzzi, Paolo; Queirolo, Maria Antonietta; Zarcone, Daniela; Giorgio, Flavia DL; Rosso, Riccardo; Santi, Leonardo; Canobbio, L; Fassio, T; Ardizzoni, A; Bruzzi, P; Queirolo, M A; Zarcone, D; Di Giorgio, F; Rosso, R; Santi, L
- Abstract
An increased incidence of thromboembolic complications occurring in cancer patients during chemotherapy was recently reported. In view of this report, a study in 49 patients receiving adjuvant chemotherapy for Stage II breast cancer was begun in order to determine the effect of antineoplastic drugs on coagulation factors and platelet function. Among the coagulation factors, a significant decrease of thrombin time and partial prothrombin time was observed, whereas platelet function tests were unchanged. This finding suggests a trend towards hypercoagulability induced by chemotherapy. This effect should be considered when chemotherapy is employed in advanced cancer patients at high risk for thrombosis.
- Subjects
ANTINEOPLASTIC agents; BLOOD coagulation disorders; BLOOD platelet aggregation; BREAST tumors; FIBRINOGEN; LONGITUDINAL method; TUMOR classification; RELATIVE medical risk; PARTIAL thromboplastin time; PROTHROMBIN time; THROMBIN time
- Publication
Cancer (0008543X), 1986, Vol 58, Issue 5, p1032
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19860901)58:5<1032::AID-CNCR2820580509>3.0.CO;2-U