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- Title
Fiber concentration in lung tissue of patients with malignant mesothelioma. A case-control study.
- Authors
Mowé, Gunnar; Gylseth, Bjørn; Hartveit, Flora; Skaug, Vidar; Mowé, G; Gylseth, B; Hartveit, F; Skaug, V
- Abstract
The risk of malignant mesothelioma associated with low-level asbestos exposure is an important unresolved issue today. We have analyzed the asbestos fiber concentration in lung tissue from 14 cases of malignant mesothelioma and 28 case-matched controls by scanning electron microscopy. The cases represent 86% of all mesotheliomas recorded by the Cancer Registry of Norway from the county of Hordaland between 1970 and 1979. Based on 1 million fibers per g of dried tissue as an indicator of cumulated asbestos exposure, the odds ratio (relative risk) was 8.5 (95% confidence limits, 2.3-31.1). Assuming that the risk of malignant mesothelioma is related to mineral fiber concentration in lung tissue, it is concluded that a fiber concentration exceeding 1 million fibers per g of dried tissue is associated with an increased risk of malignant mesothelioma. Furthermore, the results are consistent with a no-threshold response.
- Subjects
NORWAY; ASBESTOS analysis; LUNG analysis; ASBESTOS; MESOTHELIOMA; OCCUPATIONAL diseases; PROBABILITY theory; PLEURAL tumors; RELATIVE medical risk
- Publication
Cancer (0008543X), 1985, Vol 56, Issue 5, p1089
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850901)56:5<1089::AID-CNCR2820560522>3.0.CO;2-Y