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- Title
Protected environment - prophylactic antibiotic program for malignant sarcomas: randomized trial during remission induction chemotherapy.
- Authors
Bodey, Gerald P.; Rodriguez, Victorio; Murphy, William K.; Burgess, M. Andrew; Benjamin, Robert S.; Bodey, G P; Rodriguez, V; Murphy, W K; Burgess, A; Benjamin, R S
- Abstract
Fifty-one valuable patients with malignant sarcomas were randomly allocated to receive three courses of remission induction chemotherapy with cyclophosphamide, vincristine, Adriamycin, and dimethyl triazeno imidazole carboxamide (CYVADIC) on the protected environment-prophylactic antibiotic for the control group (P = 0.22). The response rates (complete plus partial) were 71% and 67%, respectively. The durations of response were similar for both groups of patients, but the PEPA patients survived substantially longer (median, 84 weeks vs. 58 weeks). The frequency of infection was significantly lower among the PEPA patients, and the doses of CYVADIC could be escalated more often among these patients. Dosage escalation was associated with a higher complete remission rate and lower fatality rate.
- Publication
Cancer (0008543X), 1981, Vol 47, Issue 10, p2422
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19810515)47:10<2422::AID-CNCR2820471017>3.0.CO;2-Y