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- Title
Co-Stimulatory Functions of Antigen-Presenting Cells.
- Authors
Johnson, Julia G.; Jenkins, Marc K.
- Abstract
Antigen-presenting cells, in addition to presenting processed antigen, provide co-stimulatory signals that are necessary for stimulating maximal lymphokineproduction by CD4+ T cells. For interleukin 2 (IL-2)-producing CD4+ T cells, the B7 molecule provides an important co-stimulatory signal through interaction with its ligand on the T-cell surface, CD28. Populations of antigen-presenting cells that express high levels of B7 (e.g., dendritic cells) are much more potent stimulators of T-cell activation than cells that fail to express B7 (e.g., resting B cells). An increase in B7 expression could therefore explain the increased accessory function gained by Langerhans cells as they leave the skin and migrate to the draining lymph node.
- Subjects
ANTIGEN presenting cells; IMMUNOCOMPETENT cells; ANTIGENS; INTERLEUKIN-2; T cells; DENDRITIC cells
- Publication
Journal of Investigative Dermatology, 1992, Vol 99, Issue 5, p62S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12669010