We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Clinical presentation and patterns of slow transit constipation do not predict coexistent upper gut dysmotility.
- Authors
Zarate, Natalia; Knowles, Charlie H; Yazaki, Etsuro; Lunnis, Peter J; Scott, S Mark
- Abstract
<bold>Background: </bold>Slow transit constipation (STC) is associated with upper gastrointestinal tract motor abnormalities in a subset of patients. This could influence the clinical approach, particularly in those rare cases where surgical management is considered.<bold>Aims: </bold>To identify factors that predict proximal gut dysmotility in patients with STC.<bold>Methods: </bold>Esophageal and small bowel motor function were evaluated in 77 patients with STC. Severity and pattern of colonic transit delay, prevalence of a co-existent rectal evacuatory disorder, and type (if present), and duration, and onset of constipation symptoms were compared.<bold>Results: </bold>Of the 77 patients studied, 43% exhibited altered motor function in the esophagus and/or small bowel. Frequency of defecation was lower in these patients than in those without upper gastrointestinal dysmotility (0.5 +/- 0.1 vs. 1.3 +/- 0.3 bowel movements/per week, respectively; P = 0.04). Severity and patterns of colonic transit delay and the mechanism associated with the onset of constipation symptoms or with their duration were similar in subjects with or without upper gastrointestinal tract dysmotility. Small bowel but not esophageal motor dysfunction was more frequently associated with a co-existent rectal evacuatory disorder (P = 0.01).<bold>Conclusion: </bold>Upper gastrointestinal tract dysmotility in patients with STC is frequent, but prediction on the basis of clinical history and characteristics of colonic transit is problematic.
- Publication
Digestive Diseases & Sciences, 2009, Vol 54, Issue 1, p122
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-008-0324-9