We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis.
- Authors
Lin, Zhiming; Bei, Jin-Xin; Shen, Meixin; Li, Qiuxia; Liao, Zetao; Zhang, Yanli; Lv, Qing; Wei, Qiujing; Low, Hui-Qi; Guo, Yun-Miao; Cao, Shuangyan; Yang, Mingcan; Hu, Zaiying; Xu, Manlong; Wang, Xinwei; Wei, Yanlin; Li, Li; Li, Chao; Li, Tianwang; Huang, Jianlin
- Abstract
To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10?10) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10?8). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10?324) and at 2p15 (rs10865331; P = 1.98 × 10?8). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.
- Subjects
CHINA; CHINESE people; ANKYLOSING spondylitis; HUMAN genome; SPONDYLOARTHROPATHIES; PHYSIOLOGY; THERAPEUTICS
- Publication
Nature Genetics, 2012, Vol 44, Issue 1, p73
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.1005