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- Title
HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population.
- Authors
Xiang Gao; Lei Han; Lan Yuan; Yongchen Yang; Guimei Gou; Hengjuan Sun; Ling Lu; Liming Bao
- Abstract
Background Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies. Genetic variability in human leukocyte antigen (HLA) genes plays an important role in the pathogenesis of PM and DM. However, few studies on the subject in Chinese populations have been reported thus far. Methods We studied the influence of HLA polymorphisms on DM and PM susceptibility by analyzing HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles in 71 adult DM patients, 20 adult PM patients, and 113 controls in a Han Chinese population. Results A positive association was found between HLA-DQA1*0104 and DM (p = 0.01; corrected p (corr) NS; odds ratio (OR) = 2.58; 95% confidence interval (CI): 1.18-5.64), while an inverse correlation was noted between HLA-DQB1*0303 and myositis patients with interstitial lung inflammation (p = 0.01; pcorr NS; OR = 0.25; 95% CI: 0.07-0.73). A positive relationship was also observed between HLA-DRB1*07 and DM (p = 0.01; pcorr NS; OR = 2.26; 95% CI: 1.12-4.59), while HLA-DRB1*03 seems to be protective against DM (p = 0.01; corr NS; OR = 0.26; 95% CI: 0.06-0.81). The lung complication was closely associated with HLADRB1* 04 (p = 0.01; corr NS; OR = 2.82; 95% CI: 1.15-6.76) and HLA-DRB1*12 (p = 0.02; corr NS; OR = 2.52; 95% CI: 1.02-6.07). The frequency of HLA-DRB1*07 was significantly higher among myositis patients with dysphagia than among controls (p = 0.01; corr NS; OR = 4.78; 95% CI: 1.03-24.42). The putative haplotype DRB1*07-DQA1*01-DQB1*02 was positively correlated with DM (p = 0.03; corr NS; OR = 2.90; 95% CI: 1.02-8.93) and the lung complication (p = 0.02; corr NS; OR = 3.45; 95% CI: 1.04-11.58). Conclusions Our results demonstrate that HLA alleles may be involved in susceptibility to adult DM and PM in the Han Chinese population.
- Subjects
POLYMYOSITIS; DERMATOMYOSITIS; HLA histocompatibility antigens; ODDS ratio; CONFIDENCE intervals
- Publication
BMC Dermatology, 2014, Vol 14, Issue 1, p1
- ISSN
1471-5945
- Publication type
Article
- DOI
10.1186/1471-5945-14-9