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- Title
Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.
- Authors
Ni, Wuhua; Li, Haiyan; Wu, Aihua; Zhang, Peili; Yang, Haiyan; Yang, Xu; Huang, Xuefeng; Jiang, Lei
- Abstract
Purpose: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. Methods: The polymorphic distributions of the four SNPs ( MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. Results: We found no evidence for an association between any of these variants ( MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. Conclusions: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
- Subjects
SINGLE nucleotide polymorphisms; FOLIC acid; MALE infertility; OLIGOSPERMIA; HUMAN genetic variation
- Publication
Journal of Assisted Reproduction & Genetics, 2015, Vol 32, Issue 3, p369
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-014-0423-9