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- Title
Short gamete co-incubation during in vitro fertilization decreases the fertilization rate and does not improve embryo quality: a prospective auto controlled study.
- Authors
Barraud-Lange, V.; Sifer, C.; Pocaté, K.; Ziyyat, A.; Martin-Pont, B.; Porcher, R.; Hugues, J. N.; Wolf, J. P.
- Abstract
Purpose Evaluate the effect of short gamete incubation on fertilization rate and embryo quality. Methods A prospective study has been performed. Two thousand five hundred and forty seven sibling oocytes from 240 couples undergoing IVF attempts were allocated to a short (1 h) or a standard (18 h) insemination procedure. Diploid fertilization rate (two pronuclei, 2PN), polyspermy (>2PN) and embryo quality were compared. Results The fertilization rate was statistically lower in the short insemination group compared to the standard insemination one (64.9% and 70.1%; P=0.039), with a similar polyspermy rate observed between the two groups. A slight, but non significant, increase was observed concerning good embryo quality rate in the short insemination group when compared to the standard insemination, both at day 2 (60.1 vs. 58.1%; P=0.06) and day 3 (53.2 vs. 48.5%; P=0.22). Conclusion This new study highlights that a 1 h gamete exposure decreases the fertilization rate and does not improve embryo quality compared with a standard 18 h insemination procedure.
- Subjects
GAMETES; GERM cells; FERTILIZATION in vitro; EGG incubation; HUMAN artificial insemination
- Publication
Journal of Assisted Reproduction & Genetics, 2008, Vol 25, Issue 7, p305
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-008-9240-3