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- Title
Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening.
- Authors
Kobayashi, Yuka; Sato, Koichiro; Kibe, Tatsuya; Seimiya, Hiroyuki; Nakamura, Asako; Yukawa, Masashi; Tsuchiya, Eiko; Ueno, Masaru
- Abstract
The article presents a study on the roles of replication protein A (RPA), a binding to single-stranded DNA generated during DNA replication and other processes, in telomere shortening. The study found that expression of mutant RPA70 in human cells caused telomere shortening. It suggests that RPA is required for telomere-length regulation in human cancer cells.
- Subjects
DNA replication; TELOMERES; CANCER cells; CHROMOSOMES; LINKAGE (Genetics)
- Publication
Bioscience, Biotechnology & Biochemistry, 2010, Vol 74, Issue 2, p382
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.90496