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- Title
The effect of pregnancy-induced hypertensive disorders on placental growth along short and long axes and neonatal outcomes.
- Authors
Phad, Neelkanth; Dahlstrom, Jane E.; Ellwood, David; Kent, Alison L.
- Abstract
Aim To assess the effect of pregnancy-induced hypertensive disorders on the growth of the placenta on the short and long axes and neonatal outcomes. Materials and Methods A retrospective cohort study of gross and histological characteristics of placentas and the fetal outcomes of normotensive and hypertensive pregnancies over a three-year period from January 2009 to December 2011 at a tertiary teaching hospital in ACT, Australia. Results Placentas and neonatal outcomes from 100 pregnancies complicated with pregnancy-induced hypertension/pre-eclampsia were studied and compared with 51 gestational age-matched placentas and neonatal outcomes from normotensive pregnancies. The median maternal age and smoking history were similar in the two groups ( P = 0.894; P = 1.00, respectively). The median pre-pregnancy weight was significantly higher ( P < 0.001) and primiparity more common ( P = 0.001) in the study group. The median weight of the placenta was significantly lower ( P < 0.001) and below the 10th centile ( P < 0.001) in the study group. Both the long and short axes of the placental disc were significantly smaller in the study group ( P = 0.002; P ≤ 0.001 respectively). Accelerated villous maturation, placental infarcts and decidual vessel vasculopathy were more common in the study group ( P < 0.001). The median birthweight and the number of infants with birthweight and length below the 10th centile were significantly higher in the study group ( P = 0.008; P < 0.001; P = 0.004, respectively). Conclusion This study demonstrates that pregnancy-induced hypertension significantly influences the growth and development of both the placenta and fetus.
- Publication
Australian & New Zealand Journal of Obstetrics & Gynaecology, 2015, Vol 55, Issue 3, p239
- ISSN
0004-8666
- Publication type
Article
- DOI
10.1111/ajo.12308