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- Title
The role of corynomycolic acids in <italic>Corynebacterium</italic>-host interaction.
- Authors
Burkovski, Andreas
- Abstract
Within the <italic>Actinobacteria</italic>, the genera <italic>Corynebacterium</italic>, <italic>Mycobacterium</italic>, <italic>Nocardia</italic> and <italic>Rhodococcus</italic> form the so-called CMNR group, also designated as mycolic acid-containing actinomycetes. Almost all members of this group are characterized by a mycolic acid layer, the mycomembrane, which covers the cell wall and is responsible for a high resistance of these bacteria against chemical and antibiotic stress. Furthermore, components of the mycomembrane are crucial for the interaction of bacteria with host cells. This review summarizes the current knowledge of mycolic acid synthesis and interaction with components of the immune system for the genus <italic>Corynebacterium</italic> with an emphasis on the pathogenic species <italic>Corynebacterium diphtheriae</italic>, <italic>Corynebacterium pseudotuberculosis</italic> and <italic>Corynebacterium ulcerans</italic> as well as the biotechnology workhorse <italic>Corynebacterium glutamicum</italic>.
- Subjects
CORYNEBACTERIUM; MYCOLIC acids; ANTIBIOTICS; CORYNEBACTERIACEAE; FATTY acids
- Publication
Antonie van Leeuwenhoek, 2018, Vol 111, Issue 5, p717
- ISSN
0003-6072
- Publication type
Article
- DOI
10.1007/s10482-018-1036-6