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- Title
Diosmetin inhibits the expression of alpha-hemolysin in Staphylococcus aureus.
- Authors
Liu, Shui; Zhou, Xuan; Li, Wenhua; Zhang, Hong; Zhang, Bing; Li, Gen; Liu, Bowen; Deng, Xuming; Peng, Liping
- Abstract
Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathogen. In the present study, we discovered that diosmetin, a natural flavonoid that occurs primarily in citrus fruits and exhibits little anti- S. aureus activity, could diminish the production of Hla in culture supernatants in a concentration-dependent manner. The analysis of cytotoxicity in the co-culture system of S. aureus and A549 epithelial cells showed that such inhibition confers significant protection against S. aureus-mediated injury. Our results suggested that diosmetin has the potential to be a new anti-virulence drug for S. aureus infection, particularly for the targeting of Hla.
- Subjects
FLAVONOIDS; HEMOLYSIS &; hemolysins; STAPHYLOCOCCUS aureus; CELL-mediated cytotoxicity; MICROBIAL virulence
- Publication
Antonie van Leeuwenhoek, 2015, Vol 108, Issue 2, p383
- ISSN
0003-6072
- Publication type
Article
- DOI
10.1007/s10482-015-0491-6