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- Title
T<sub>1</sub> measurement of flowing blood and arterial input function determination for quantitative 3D T<sub>1</sub>-weighted DCE-MRI.
- Authors
Cheng, Hai-Ling Margaret
- Abstract
Purpose To propose a simple, accurate method for measuring T1 in flowing blood and the arterial input function (AIF), and to evaluate the impact on dynamic contrast-enhanced MRI (DCE-MRI) quantification of pharmacokinetic parameters. Materials and Methods A total of 10 rabbits were scanned at 1.5 Tesla and administered a bolus of Gadomer. Preinjection T1 and AIF measurements were acquired in the iliac arteries using a rapid three-dimensional (3D) spoiled gradient recalled echo (SPGR) approach. Correction was made for imperfect B1 fields, in-flow, and partial volume effects. DCE-MRI parameters blood volume ( vb) and endothelial transfer constant ( Ktrans) in resting skeletal muscle were estimated from pharmacokinetic analysis using individually measured AIFs. Literature comparisons were made to assess accuracy. Results Blood T1 was more accurate and precise after correction for B1 and partial volume errors (1267 ± 72 msec). Measured AIFs followed reported biexponential decay characteristics for Gadomer clearance in rabbits. Parameters vb (2.47 ± 0.65%) and Ktrans (3.6 ± 1.0 × 10-3 minute-1) derived from AIFs based on corrected blood T1s were more reproducible and in better agreement with literature values. Conclusion The proposed method enables accurate in vivo blood T1 and AIF measurements and can be easily implemented in a range of DCE-MRI applications to improve both the accuracy and reproducibility of pharmacokinetic parameters. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2007, Vol 25, Issue 5, p1073
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.20898