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- Title
Factors influencing health-related quality of life after gastrectomy for cancer.
- Authors
Brenkman, Hylke J. F.; Tegels, Juul J. W.; Ruurda, Jelle P.; Luyer, Misha D. P.; Kouwenhoven, Ewout A.; Draaisma, Werner A.; van der Peet, Donald L.; Wijnhoven, Bas P. L.; Stoot, Jan H. M. B.; van Hillegersberg, Richard; on behalf of the LOGICA Study Group
- Abstract
Aim: Insight in health-related quality of life (HRQoL) may improve clinical decision making and inform patients about the long-term effects of gastrectomy. This study aimed to evaluate and identify factors associated with HRQoL after gastrectomy.Methods: This cross-sectional study used prospective databases from seven Dutch centers (2001-2015) including patients who underwent gastrectomy for cancer. Between July 2015 and November 2016, European Organization for Research and Treatment of Cancer HRQoL questionnaires QLQ-C30 and QLQ-STO22 were sent to all surviving patients without recurrence. The QLQ-C30 scores were compared to a Dutch reference population using a one-sample <italic>t</italic> test. Spearman’s rank test was used to correlate time after surgery to HRQoL, and multivariable linear regression was performed to identify factors associated with HRQoL.Results: A total of 222 of 274 (81.0%) patients completed the questionnaires. Median follow-up was 29 months (range, 3-171) and 86.9% of patients had a follow-up >1 year. The majority of patients had undergone neoadjuvant treatment (64.4%) and total gastrectomy (52.7%). Minimally invasive gastrectomy (MIG) was performed in 50% of the patients. Compared to the general population, gastrectomy patients scored significantly worse on most functional and symptom scales (<italic>p</italic> < 0.001) and slightly worse on global HRQoL (78 vs. 74, <italic>p</italic> = 0.012). Time elapsed since surgery did not correlate with global HRQoL (Spearman’s ρ = 0.06, <italic>p</italic> = 0.384). Distal gastrectomy, neoadjuvant treatment, and MIG were associated with better HRQoL (<italic>p</italic> < 0.050).Conclusion: After gastrectomy, patients encounter functional impairments and symptoms, but experience only a slightly impaired global HRQoL. Distal gastrectomy, the ability to receive neoadjuvant treatment, and MIG may be associated with HRQoL benefits.
- Subjects
QUALITY of life; GASTRECTOMY; CANCER treatment; SURGICAL complications; CANCER chemotherapy
- Publication
Gastric Cancer, 2018, Vol 21, Issue 3, p524
- ISSN
1436-3291
- Publication type
Article
- DOI
10.1007/s10120-017-0771-0