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- Title
Evaluation of the Impact of Severe Endometriosis on Embryo Morphokinetics.
- Authors
SEZER, Feyzan; ÖZKARA, Gülçin; YELKE, Hakan Kadir; ÖZER, Gönül; KAHRAMAN, Semra
- Abstract
Introduction: Endometriosis is one of the leading causes of infertility and affects approximately one-third of women who apply for in vitro fertilization treatment. Controversial results have been reported regarding the effect of endometriozis on both morphological and dynamic characteristics of embryos. Thus, we investigated the impact of severe endometriosis (SE) on embryo morphokinetics. Method: This was a retrospective comparative analysis including a total of 1280 embryos [SE: 729, tubal factor (control): 551] that were incubated at the Time-Lapse Monitoring System in Memorial Şişli Hospital, ART and Genetics Center between October 2011 and July 2023. Patients with =38 years, bosy mass index (BMI) >30 and partners having severe male factors were excluded from the study. Morphokinetic parameters of embryos were compared using Student's t-test with SPSS 28.0. Results: There was a homogenous distribution in terms of female age, BMI, basal follicle stimulating hormone, anti-Mullerian hormone levels, and total and mature oocyte count between the study groups. Although all morphokinetic parameters were significantly delayed in the SE group compared with the control group (p<0.05), no statistical significance was obtained in terms of tSC and tEB (p>0.05). The duration of the first, second, and third embryo cell cycles (ECC1, ECC2, and ECC3), synchronization of cell divisions (S2: t4-t3) and cleavage patterns (S3: t8-t5) were also found to be statistically significant between the SE and control groups (p<0.05). Conclusion: SE may have an effect on embryonic cell division and could change the morphokinetic parameters of in vitro developing embryos. Prospective studies with larger cohorts are needed to better understand the relationship between SE and embryo morphokinetics.
- Subjects
ENDOMETRIOSIS; INFERTILITY; ANTI-Mullerian hormone; EMBRYOS; FERTILIZATION in vitro; CELL division
- Publication
Bezmialem Science, 2024, Vol 13, pS15
- ISSN
2148-2373
- Publication type
Abstract