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- Title
Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus.
- Authors
Lu, Mary; Bernatsky, Sasha; Ramsey-Goldman, Rosalind; Petri, Michelle; Manzi, Susan; Urowitz, Murray B.; Gladman, Dafna; Fortin, Paul R.; Ginzler, Ellen M.; Yelin, Edward; Bae, Sang-Cheol; Wallace, Daniel J.; Jacobsen, Soren; Dooley, Mary Anne; Peschken, Christine A.; Alarcón, Graciela S.; Nived, Ola; Gottesman, Lena; Criswell, Lindsey A.; Sturfelt, Gunnar
- Abstract
Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. © 2013 S. Karger AG, Basel
- Subjects
CANADA; EUROPE; KOREA; UNITED States; ACADEMIC medical centers; AGE distribution; CONFIDENCE intervals; REPORTING of diseases; EPIDEMIOLOGY; MEDICAL cooperation; RESEARCH; RESEARCH funding; SYSTEMIC lupus erythematosus; DATA analysis; DISEASE prevalence; HEMATOLOGIC malignancies
- Publication
Oncology, 2013, Vol 85, Issue 4, p235
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000350165