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- Title
Oomicidal activity of polypyrrole nanoparticles against Pythium insidiosum.
- Authors
Ianiski, Lara Baccarin; Maciel, Aline Fontanella; Weiblen, Carla; Stibbe, Paula Cristina; de Oliveira, Helinando Pequeno; da Costa, Mateus Matiuzzi; Sangioni, Luis Antônio; Pereira, Daniela Isabel Brayer; Santurio, Janio Morais; Botton, Sônia de Avila
- Abstract
This study evaluated in-vitro action of a new molecule, the polypyrrole nanoparticles (Ppy-NP), against Pythium insidiosum isolates using M38-A2/CLSI; the minimal inhibitory (MIC) and minimal oomicidal (MOC) concentrations were also determined. Additionally, changes in the hyphae wall of P. insidiosum CBS 575.85 treated with Ppy-NP were evaluated by scanning electron microscopy (SEM). The MIC100 and MOC for all isolates ranged from 8 to 32 μg mL−1, and the MIC90 and MIC50 were 16 μg mL−1. The SEM showed structural damage to the hyphae of P. insidisoum treated with Ppy-NP, as hyphae surfaces with less turgidity were found, thereby showing scaling and ruptures compared to the control (untreated hyphae). Our findings highlighted the anti- P. insidiosum properties of Ppy-NP proved to be a promising candidate for research using pythiosis experimental models.
- Subjects
PYTHIUM; POLYPYRROLE; SCANNING electron microscopy; NANOPARTICLES
- Publication
Letters in Applied Microbiology, 2023, Vol 76, Issue 1, p1
- ISSN
0266-8254
- Publication type
Article
- DOI
10.1093/lambio/ovac020