We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mammographic Density Phenotypes and Risk of Breast Cancer: A Meta-analysis.
- Authors
Pettersson, Andreas; Graff, Rebecca E.; Ursin, Giske; Silva, Isabel dos Santos; McCormack, Valerie; Baglietto, Laura; Vachon, Celine; Bakker, Marije F.; Giles, Graham G.; Kee Seng Chia; Czene, Kamila; Eriksson, Louise; Hall, Per; Hartman, Mikael; Warren, Ruth M. L.; Hislop, Greg; Chiarelli, Anna M.; Hopper, John L.; Krishnan, Kavitha; Jingmei Li
- Abstract
Background Fibroglandular breast tissue appears dense on mammogrann, whereas fat appears nondense. It is unclear whether absolute or percentage dense area more strongly predicts breast cancer risk and whether absolute nondense area is independently associated with risk. Methods We conducted a meta-analysis of 13 case-control studies providing results from logistic regressions for associations between one standard deviation (SD) increments in mammographic density phenotypes and breast cancer risk. We used random-effects models to calculate pooled odds ratios and 95% confidence intervals (CIs). All tests were two-sided with P less than .05 considered to be statistically significant. Results Among premenopausal women (n = 1776 case patients; n = 2834 control subjects), summary odds ratios were 1.37 (95% CI = 1.29 to 1.47) for absolute dense area, 0.78 (95% CI = 0.71 to 0.86) for absolute nondense area, and 1.52 (95% CI = 1.39 to 1.66) for percentage dense area when pooling estimates adjusted for age, body mass index, and parity. Corresponding odds ratios among postmenopausal women (n = 6643 case patients; n = 11 187 control subjects) were 1.38 (95% CI = 1.31 to 1.44), 0.79 (95% CI = 0.73 to 0.85), and 1.53 (95% Cl = 1.44 to 1.64). After additional adjustment for absolute dense area, associations between absolute nondense area and breast cancer became attenuated or null in several studies and summary odds ratios became 0.82 (95% CI = 0.71 to 0.94; Pheterogeneity = -02) for premenopausal and 0.85 (95% CI = 0.75 to 0.96; Pheterogeneity < -01 ) for postmenopausal women. Conclusions The results suggest that percentage dense area is a stronger breast cancer risk factor than absolute dense area. Absolute nondense area was inversely associated with breast cancer risk, but it is unclear whether the association is independent of absolute dense area.
- Subjects
MAMMOGRAMS; BREAST cancer risk factors; BREAST cancer diagnosis; CANCER in women; BODY mass index
- Publication
JNCI: Journal of the National Cancer Institute, 2014, Vol 106, Issue 5, p1
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/dju078