We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood
- Authors
Lommatzsch, Marek; Quarcoo, David; Schulte-Herbrüggen, Olaf; Weber, Heike; Virchow, Johann Christian; Renz, Harald; Braun, Armin
- Abstract
Abstract: There is growing evidence that target-derived neurotrophins regulate the function of visceral neurons after birth. However, the postnatal profile of neurotrophin supply from internal organs is poorly described. In this study, we compared neurotrophin concentrations in lysates of murine peripheral target tissues (lung, heart, liver, colon, spleen, thymus, kidney and urinary bladder) at different time points after birth. In most organs, there was a decrease of neurotrophin concentrations in the first weeks after birth. In contrast, there were characteristic increases of specific neurotrophins during adolescence or adulthood. These increases were found for nerve growth factor (NGF) in the heart, thymus, kidney and liver, for brain-derived neurotrophic factor (BDNF) in the lung, and for neurotrophin-3 (NT-3) in the colon. In conclusion, we show that neurotrophins display a very differential and dynamic profile in internal organs after birth.
- Subjects
NEURON development; ORGANS (Anatomy); NERVOUS system; NERVE growth factor
- Publication
International Journal of Developmental Neuroscience, 2005, Vol 23, Issue 6, p495
- ISSN
0736-5748
- Publication type
Article
- DOI
10.1016/j.ijdevneu.2005.05.009