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- Title
Effects of risperidone on energy balance in female C57BL/6J mice.
- Authors
Li, Xingsheng; Johnson, Maria S.; Smith, Daniel L.; Li, Yan; Kesterson, Robert A.; Allison, David B.; Nagy, Tim R.
- Abstract
Objective To investigate the effect of risperidone on energy expenditure and weight gain in female C57BL/6J mice. Design and Methods Body weight and composition, food intake, energy expenditure, and activity were determined weekly. mRNA expression of uncoupling protein 1 in brown adipose tissue, orexin, and brain-derived neurotrophic factor in the hypothalamus were quantified using real-time PCR. Results Risperidone tended to induce a greater body weight gain ( P = 0.052) and significantly higher food intake ( P = 0.038) relative to the placebo-treated group. Risperidone-treated mice had a higher resting energy expenditure ( P = 0.001) and total energy expenditure (TEE) ( P = 0.005) than the placebo group. There were no effects of treatment, time, and treatment by time on non-resting (or activity-related) energy expenditure between groups. Risperidone-treated mice showed a significantly lesser locomotor activity than placebo-treated mice over 3 weeks ( P < 0.001). Risperidone induced a higher UCP1 mRNA ( P = 0.003) and a lower orexin mRNA ( P = 0.001) than placebo. Conclusion Risperidone-induced weight gain is associated with hyperphagia and a reduction in locomotor activity in C57BL/6J mice. Additionally, higher total and resting energy expenditure were accompanied by higher levels of UCP1 mRNA in BAT. The increased TEE could not offset the total intake of energy through risperidone-induced hyperphagia, therefore resulting in weight gain in female C57BL/6J mice.
- Subjects
RISPERIDONE; WEIGHT gain; CALORIC expenditure; BIOENERGETICS; LOCOMOTION
- Publication
Obesity (19307381), 2013, Vol 21, Issue 9, p1850
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1002/oby.20350