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- Title
A pathological complete response after nivolumab plus ipilimumab therapy for DNA mismatch repair-deficient/microsatellite instability-high metastatic colon cancer: A case report.
- Authors
Igaue, Shota; Okuno, Takayuki; Ishibashi, Hajime; Nemoto, Masaru; Hiyoshi, Masaya; Kawasaki, Hiroshi; Saitoh, Hitoaki; Saitoh, Makoto; Akagi, Kiwamu; Yamamoto, Junji
- Abstract
The standard treatment for colorectal cancer has always been surgery and chemotherapy, which may be used in combination to treat patients. Immune checkpoint inhibitors have been a significant advancement in the standard treatment of metastatic, unresectable colorectal cancer with deficient mismatch repair. However, little information is available about their use in neoadjuvant and conversion settings with only a few case reports and only one phase 2 trial. The present study reports the case of a large, locally advanced right-sided metastatic deficient mismatch repair/microsatellite instability-high colon cancer, which showed a pathological complete response after combination treatment with nivolumab and ipilimumab. To the best of our knowledge, resected metastatic colon cancer with a pathological complete response after treatment using dual immune checkpoint inhibitors has not been previously reported. Overall, this case report suggests the use of immune checkpoint inhibitors before colorectal surgery.
- Subjects
COLON cancer; HEREDITARY nonpolyposis colorectal cancer; IMMUNE checkpoint inhibitors; METASTASIS; NIVOLUMAB; COLORECTAL cancer
- Publication
Oncology Letters, 2022, Vol 24, Issue 1, pN.PAG
- ISSN
1792-1074
- Publication type
Case Study
- DOI
10.3892/ol.2022.13332