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- Title
Wpływ stężenia kwasu moczowego na rokowanie odległe pacjentów z zawałem mięśnia sercowego bez uniesienia odcinka ST.
- Authors
Kuźma, Łukasz; Kurasz, Anna; Niwińska, Marta; Kulikowska, Agata; Małyszko, Jolanta; Bachórzewska‑Gajewska, Hanna; Dobrzycki, Sławomir
- Abstract
Cardiovascular diseases (CVD) are the leading cause of death worldwide. Many studies have reported the association between serum uric acid (sUA) and CVD its role as a risk marker for mortality. Aims: To assess the relationship between sUA levels and long‑term prognosis of patients with NSTEMI. METHODS The study was conducted at the Clinical Hospital of Bialystok. Based on medical records, 9328 patients were hospitalized between 2011 and 2013, of which 726 were NSTEMI. Exclusion criteria were diagnosed gout, neoplasm, taking allopurinol and with eGFR<15 ml/min. The average observation time was 2317 days. RESULTS A total of 526 patients were qualified for the analysis and men were in majority (68.25%, N = 359), with a mean age of 68.31 years (SD = 11.74). Norm of sUA was exceeded in 23% patients. Hyperuricemia is more likely to occur in women (RR 1.55, 95% CI: 1.139–2.127, P = 0.005), and patients with chronic kidney disease (RR: 3.752, 95% CI: 2.732–5.154, P <0.001) and higher BMI (RR: 1.069, 95% CI: 1.038–1.101, P <0.001). 31.9% patients died during the study, more often with hiuperuricemia (42.98% vs. 28.64%, P = 0.01) and increasing sUA level the occurrence of death increases (P <0.001). Indepented risk factors of death were age (RR: 1.074, 95% CI: 1.050–1.096, P <0.001), sUA (RR: 1.172, 95% CI: 1.042–1.319, P = 0.041), ejection fraction (RR: 0.943, 95% CI: 0.924–0.963, P <0.001) hemoglobin concentration (RR: 0.757, 95% CI: 0.657–0.872, P <0.001). CONCLUSIONS Serum UA concertation is independent risk factor in long‑term mortality in patients following NSTEMI and is associated with higher in‑hospital death rate. Secondary prevention after NSTEMI should consider management of the sUA levels.
- Subjects
MYOCARDIAL infarction diagnosis; MYOCARDIAL infarction-related mortality; CONFIDENCE intervals; MEDICAL records; MYOCARDIAL infarction; URIC acid; DESCRIPTIVE statistics; HOSPITAL mortality; ACQUISITION of data methodology; EVALUATION
- Publication
Polish Heart Journal / Kardiologia Polska, 2020, Vol 78, p167
- ISSN
0022-9032
- Publication type
Article