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- Title
SKA3/PTTG1/c‐MYC signal loop drives the progression of colorectal cancer.
- Authors
Zhang, Hao; Chang, Zewen; Wang, Chunlin; Yuan, Ziming; Liu, Yunxiao; Wang, Yuliuming; Zhang, Weiyuan; Zhong, Yuchen; Wang, Meng; Zou, Chaoxia; Tang, Qingchao; Hu, Hanqing; Wang, Guiyu
- Abstract
This article explores the role of the SKA3/PTTG1/c-MYC signal loop in the development of colorectal cancer (CRC). The researchers discovered that SKA3, a component of the SKA complex, is elevated in CRC tissues and is linked to poor overall survival. Through laboratory experiments, they demonstrated that SKA3 promotes the proliferation, migration, and invasion of CRC cells. The study also revealed a positive association between SKA3 and c-MYC expression, and identified PTTG1 as a transcriptional activator for c-MYC. These findings suggest that targeting the SKA3/PTTG1/c-MYC axis could be a potential therapeutic approach for CRC.
- Subjects
COLORECTAL cancer; WESTERN immunoblotting; COLONY-forming units assay; PROLIFERATING cell nuclear antigen; CANCER invasiveness
- Publication
Clinical & Translational Medicine, 2024, Vol 14, Issue 6, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1730