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- Title
PAK5‐stabilized Smuc confers renal cell carcinoma metastasis.
- Authors
Huo, Fu‐Chun; Zhu, Zhi‐Man; Du, Qiu‐Ying; Pei, Dong‐Sheng
- Abstract
*p < 0.05; **p < 0.01; ***p < 0.001; # > 0.05 gl In conclusion, we identify Smuc as a novel downstream partner of PAK5 and demonstrate that PAK5-mediated Smuc phosphorylation impairs its ubiquitination degradation (Figure 3K). PAK5-stabilized Smuc confers renal cell carcinoma metastasis (C and D) Different constructs (PAK5-WT, PAK5-S573N and PAK5-K478M) of PAK5 were transfected into 786O cells. (B) In vitro phosphorylation assay was employed to explore the effects of different PAK5 constructs on the phosphorylation level of Smuc/peptide #2 (potential PAK5-phosphorylation site/Ser287 of Smuc).
- Subjects
RENAL cell carcinoma; METASTASIS; CANCER cells; METASTATIC breast cancer; PROGNOSIS
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 9, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.559