We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Evidence for increased chylomicron remnants in rheumatoid arthritis.
- Authors
Burggraaf, Benjamin; van Breukelen‐van der Stoep, Deborah F.; van Zeben, Jendé; van der Meulen, Noelle; van de Geijn, Gert‐Jan M.; Liem, Anho; Valdivielso, Pedro; Rioja Villodres, José; Ramírez‐Bollero, José; van der Zwan, Ellen; Castro Cabezas, Manuel
- Abstract
Abstract: Background: Levels of apolipoprotein (apo) B48 may be increased in conditions associated with systemic inflammation and increased cardiovascular disease (CVD) risk such as rheumatoid arthritis (RA). We aimed to evaluate apo B48 levels in patients with RA in relation to subclinical atherosclerosis. Methods: Patients with RA (without CVD) and controls without RA but with high CVD risk (based on the presence of diabetes mellitus or a history of CVD) and healthy controls were included in this cross‐sectional study. Carotid intima‐media thickness (cIMT) was measured as a surrogate for vascular damage. Results: In total, 312 patients with RA, 65 controls with high CVD risk and 36 healthy controls were included. Patients with RA had the highest mean apo B48 (10.00 ± 6.65 mg/L) compared to controls with high CVD risk and healthy controls (8.37 ± 5.16 and 5.22 ± 2.46, <italic>P </italic><<italic> </italic>.001). Triglycerides levels were comparable with controls. In RA, apo B48 correlated positively with triglycerides (<italic>r</italic> = .645; <italic>P </italic><<italic> </italic>.001) but not with cIMT. However, in RA subjects not using lipid or blood pressure lowering medication, a weak correlation was found with cIMT (<italic>r</italic> = .157; <italic>P </italic>=<italic> </italic>.014). RA patients in the highest apo B48 tertile were more often rheumatoid factor positive and anti‐CCP positive compared to the lowest tertile. Conclusion: Rheumatoid arthritis patients have higher levels of apo B48 compared to controls with high CVD risk and healthy controls, with normal levels of triglycerides. This accumulation of atherogenic chylomicron remnants may contribute to the elevated CVD risk in RA patients.
- Subjects
CHYLOMICRONS; RHEUMATOID arthritis; APOLIPOPROTEINS; CARDIOVASCULAR diseases risk factors; ATHEROSCLEROSIS
- Publication
European Journal of Clinical Investigation, 2018, Vol 48, Issue 2, p1
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12873