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- Title
Delayed ulceration following combination pulse dye laser and topical sirolimus treatment for port wine birthmarks: A case series.
- Authors
Hobayan, Catherine Grace P.; Nourse, Elizabeth J.; Paradiso, Michela M.; Fernandez Faith, Esteban
- Abstract
Port wine birthmarks (PWB) are capillary vascular malformations within the papillary and reticular dermis, most commonly occurring on the head and neck and may darken and thicken with age. Pulsed dye laser (PDL) is the gold standard of treatment for PWB as it selectively targets involved vessels. Sirolimus is a macrolide antibiotic that selectively inhibits mammalian target of rapamycin, thereby suppressing the angiogenesis pathways that can be activated by PDL. Sirolimus and PDL may be used together to treat PWB. We present a case series describing three cases of delayed ulceration and systemic sirolimus absorption following combination therapy, highlighting a potential complication and patient safety concern.
- Subjects
DYE lasers; RAPAMYCIN; NEVUS; LASER pulses; MACROLIDE antibiotics
- Publication
Pediatric Dermatology, 2024, Vol 41, Issue 1, p108
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/pde.15409