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- Title
The GABA[sub A] receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone.
- Authors
Lancel, M.; Faulhaber, Johannes; Holsboer, Florian; Rupprecht, Rainer
- Abstract
Abstract Progesterone has been shown to exert benzodiazepine-like effects on sleep, which suggests that they are mediated by an agonistic modulation of GABA[sub A] receptor functioning. To assess the involvement of GABA[sub A] receptors, we investigated the sleep responses to one dose of the GABA[sub A] antagonist picrotoxin (1.5 mg/kg) and progesterone (90 mg/kg), administered IP to eight rats alone and in combination, during the first 4 post-injection hours. Compared with vehicle, picrotoxin significantly delayed the latency to non-rapid eye movement sleep (non-REMS) and thereby decreased all sleep states, but barely affected the EEG activity within non-REMS. Progesterone significantly shortened non-REMS latency, increased pre-REMS, depressed low-frequency EEG activity (<8 Hz) and augmented EEG activity in the higher frequencies within non-REMS. Except for the changes in high-frequency EEG activity, picrotoxin attenuated all effects of progesterone. These findings support the notion that GABA[sub A] receptors play an important role in the sleep effects of progesterone.
- Subjects
PROGESTERONE; GABA antagonists; PICROTOXIN; SLEEP physiology; PSYCHOPHARMACOLOGY; PHYSIOLOGY
- Publication
Psychopharmacology, 1999, Vol 141, Issue 2, p213
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130050827