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- Title
High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension.
- Authors
Wasilewska, Anna; Tenderenda, Edyta; Taranta-Janusz, Katarzyna; Zoch-Zwierz, Walentyna
- Abstract
The purpose of the study was to investigate serum uric acid (SUA), high-sensitivity C-reactive protein (hs-CRP) and mean platelet volume (MPV) in pre-hypertensive (PH) and hypertensive (HT) children and adolescents. The study group consisted of 80 patients aged 10–19 years subdivided into PH and HT groups according to mean daytime or night-time systolic or diastolic blood pressure (BP) levels (>90th percentile, but <95th percentile and ≥95th percentile, respectively). The control group (C) contained 25 normotensive subjects. Serum hs-CRP level was determined by a nephelometric method (Behring); platelets (PLTs) were counted, and MPV was assessed by a Coulter Analyzer MAXM. SUA was measured with an Hitachi instrument. The median SUA and hs-CRP levels in PH and HT subjects were significantly higher than those of the controls ( P < 0.01) and were higher in the HT group than in the PH group ( P < 0.05). An increase in SUA above 5.5 mg/dl was associated with an increase in hs-CRP [odds ratio (OR) 4.8; confidence interval (CI) 1.3–17.4; P < 0.01]. MPV values in the PH group did not differ from those of the controls ( P > 0.05), but it was significantly higher in HT patients ( P < 0.01). Serum hs-CRP and MPV concentrations were positively correlated with all BP measurements except night-time diastolic blood pressure (DBP). We demonstrated that, in HT children and adolescents, increased SUA with a parallel increase in hs-CRP and PLTs with MPV is observed. Although large, multicentre, prospective studies are needed to confirm this observation, hyperuricaemia seems to be associated with an increase in hs-CRP in PH and HT patients.
- Subjects
HYPERTENSION in children; HYPERTENSION in adolescence; URIC acid; C-reactive protein; BLOOD platelets; HYPERURICEMIA
- Publication
Pediatric Nephrology, 2010, Vol 25, Issue 8, p1519
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-010-1513-2