We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mid-aortic syndrome: long-term outcome of 36 children.
- Authors
Tummolo, Albina; Marks, Stephen D.; Stadermann, Marike; Roebuck, Derek J.; McLaren, Clare A.; Hamilton, George; Dillon, Michael J.; Tullus, Kjell
- Abstract
The clinical characteristics and outcomes of children with mid-aortic syndrome (MAS) and the effectiveness of different therapeutic approaches in reducing hypertension are still debated. We conducted a single-centre retrospective review of the records of children with MAS over 30 years. Children with angiographic evidence of a narrowed abdominal aorta were included. Therapeutic approaches included medical management, percutaneous transluminal angioplasty and/or surgical intervention. Thirty-six children had presented at a median age of 2.7 years (10 days–10 years). Thirteen (36%) patients had associated syndromes, and 44% had been diagnosed with cerebrovascular disease. All patients had involvement of multiple arteries. The mortality rate was 8% after a median follow-up period of 4.5 (range 1.1–19.7) years. Among the children who survived, 90% had obtained a reduction in their blood pressure (BP). Of the patients, 76% had had a normal estimated glomerular filtration rate (eGFR) at the last follow-up examination. Seventeen percent (six of 36) had renal dysfunction at presentation. Although MAS is a severe and widespread disease, in most cases it can be effectively treated with a combination of medical, angioplasty and surgical interventions.
- Subjects
AORTIC diseases; ABDOMINAL aorta; CEREBROVASCULAR disease in children; ARTERIAL dilatation; RENAL artery diseases; ANGIOPLASTY
- Publication
Pediatric Nephrology, 2009, Vol 24, Issue 11, p2225
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-009-1242-6