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- Title
HLA homozygosity and haplotype bias among patients with chronic lymphocytic leukemia: implications for disease control by physiological immune surveillance.
- Authors
Shah, N.; Decker, W. K.; Lapushin, R.; Xing, D.; Robinson, S. N.; Yang, H.; Parmar, S.; Tung, S. S.; O'Brien, S.; Fernandez-Viña, M.; Shpall, E. J.; Wierda, W. G.; Fernandez-Viña, M
- Abstract
The article presents a study which demonstrates chronic lymphocytic leukemia (CLL) patients with advance diseases exhibits bias towards homozygosity at human leukocyte antigen (HLA) loci as it limits the diversity of antigen presentation and provides a nascent tumor an advantage for immune escape. Examined are the medical records of patients with advanced CLL who undergone HLA typing. It was found out that the progression of the disease may be influenced by HLA homozygosity and haplotype bias.
- Subjects
RESEARCH bias; CHRONIC lymphocytic leukemia diagnosis; LYMPHOPROLIFERATIVE disorders; HLA histocompatibility antigens; IMMUNE complexes; ANTIGEN presenting cells; EPITOPES; CELLULAR immunity; CHRONIC lymphocytic leukemia; SURVIVAL analysis (Biometry); HAPLOTYPES; GENOTYPES
- Publication
Leukemia (08876924), 2011, Vol 25, Issue 6, p1036
- ISSN
0887-6924
- Publication type
letter
- DOI
10.1038/leu.2011.30