We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Plasma marine n-3 polyunsaturated fatty acids and cardiovascular risk factors: data from the ACE 1950 study.
- Authors
Chandra, Anupam; Røsjø, Helge; Eide, Ivar Anders; Vigen, Thea; Ihle-Hansen, Håkon; Orstad, Eivind Bjørkan; Rønning, Ole Morten; Lyngbakken, Magnus Nakrem; Berge, Trygve; Schmidt, Erik Berg; Omland, Torbjørn; Tveit, Arnljot; Svensson, My
- Abstract
Purpose: A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) might improve cardiovascular (CV) health. We conducted a cross-sectional study to investigate associations between plasma phospholipid levels of marine n-3 PUFAs and CV risk factors, educational level, physical activity and smoking habits. Methods: A total of 3706 individuals from a general population, all born in 1950 and residing in Akershus County, Norway, were included in this study. The main statistical approach was multivariable adjusted linear regression. Results: Plasma marine n-3 PUFA levels ranged from 2.7 to 20.3 wt%, with a median level of 7.7 wt% (interquartile range 4.3–11.1 wt%). High levels of plasma marine n-3 PUFAs were associated with lower serum triglycerides [Standardized regression coefficient (Std.β-coeff.) − 0.14, p < 0.001], body mass index (Std. β-coeff. −0.08, p < 0.001), serum creatinine (Std. β-coeff. -0.03, p = 0.05), C-reactive protein levels (Std. β-coeff. – 0.03, p = 0.04), higher levels of serum high-density lipoprotein cholesterol (Std. β-coeff. 0.08, p < 0.001) and low-density lipoprotein cholesterol (Std. β-coeff. 0.04, p = 0.003). High levels of plasma marine n-3 PUFAs were also associated with lower glycated hemoglobin (Std. β-coeff. – 0.04, p = 0.01), however, only in individuals without diabetes. We found no associations between plasma marine n-3 PUFA levels and fasting plasma glucose or carotid intima-media thickness. High levels of plasma marine n-3 PUFAs were associated with higher educational level, more physical activity and lower prevalence of smoking. Conclusion: In this cross-sectional study of Norwegian individuals born in 1950, high levels of plasma marine n-3 PUFAs were favourably associated with several CV risk factors, suggesting that fish consumption might improve CV health.
- Subjects
NORWAY; BLOOD sugar; C-reactive protein; CARDIOVASCULAR diseases risk factors; CREATININE; HEMOGLOBINS; HIGH density lipoproteins; LOW density lipoproteins; OMEGA-3 fatty acids; PHOSPHOLIPIDS; SMOKING; TRIGLYCERIDES; DOCOSAHEXAENOIC acid; EICOSAPENTAENOIC acid; MULTIPLE regression analysis; EDUCATIONAL attainment; BODY mass index; DISEASE prevalence; CROSS-sectional method; PHYSICAL activity; CAROTID intima-media thickness
- Publication
European Journal of Nutrition, 2020, Vol 59, Issue 4, p1505
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-019-02007-3