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- Title
Antimicrobial Diterpene Alkaloids from an Agelas citrina Sponge Collected in the Yucatán Peninsula.
- Authors
Pech-Puch, Dawrin; Forero, Abel M.; Fuentes-Monteverde, Juan Carlos; Lasarte-Monterrubio, Cristina; Martinez-Guitian, Marta; González-Salas, Carlos; Guillén-Hernández, Sergio; Villegas-Hernández, Harold; Beceiro, Alejandro; Griesinger, Christian; Rodríguez, Jaime; Jiménez, Carlos
- Abstract
Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and (+)-agelasidine C (6), were isolated from the sponge Agelas citrina, collected on the coasts of the Yucatán Peninsula (Mexico). Their chemical structures were elucidated by 1D and 2D NMR spectroscopy, HRESIMS techniques, and a comparison with literature data. Although the synthesis of (+)-ent-agelasine F (4) has been previously reported, this is the first time that it was isolated as a natural product. The evaluation of the antimicrobial activity against the Gram-positive pathogens Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis showed that all of them were active, with (+)-10-epiagelasine B (2) being the most active compound with an MIC in the range of 1–8 µg/mL. On the other hand, the Gram-negative pathogenes Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae were also evaluated, and only (+)-agelasine B (5) showed a moderate antibacterial activity with a MIC value of 16 μg/mL.
- Subjects
YUCATAN (Mexico : State); ACINETOBACTER baumannii; GRAM-negative bacteria; NUCLEAR magnetic resonance spectroscopy; PENINSULAS; KLEBSIELLA pneumoniae; STREPTOCOCCUS pneumoniae
- Publication
Marine Drugs, 2022, Vol 20, Issue 5, p298
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md20050298