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- Title
Higher Incidence Rates of Hypothyroidism and Late TSH Rise in Preterm Very-Low-Birth-Weight Infants at a Tertiary Care Center.
- Authors
Tfayli, Hala; Charafeddine, Lama; Tamim, Hani; Saade, Joanne; Daher, Rose T.; Yunis, Khalid
- Abstract
<bold><italic>Background/Aims:</italic></bold> Preterm newborns with a very low birth weight (VLBW) of < 1,500 g have an atypical form of hypothyroidism with a delayed rise in TSH, necessitating a second newborn screening specimen collection. The aims of this study were to survey the compliance with second newborn screening to detect delayed TSH rise in VLBW preterm infants at a tertiary care center, and to determine the rate of atypical hypothyroidism. <bold><italic>Methods:</italic></bold> Retrospective review of the records of 104 preterm VLBW infants. Late TSH rise was defined as an increase in TSH concentration after 14 days of age in the presence of a normal initial screen. <bold><italic>Results:</italic></bold> The compliance rate was 92% for the second screening. High rates of hypothyroidism (16.3%) and of late TSH rise (4.8%) were detected. Patients with hypothyroidism had a significantly lower birth weight (<italic>p</italic> = 0.01) and longer hospital stay (<italic>p</italic> = 0.004). Patients with late versus those with early TSH rise had a significantly lower mean birth weight (851 ± 302 vs. 1,191 ± 121 g, <italic>p</italic> = 0.004). <bold><italic>Conclusion:</italic></bold> The rates of early and late TSH rise in this VLBW population were higher than those in the literature and could be due to the use of povidone-iodine disinfectants. The yield of a second TSH screening in this study was high indicating the need for vigilance in screening VLBW preterm infants.
- Subjects
HYPOTHYROIDISM; THYROTROPIN; PREMATURE infants
- Publication
Hormone Research in Paediatrics, 2018, Vol 89, Issue 4, p224
- ISSN
1663-2818
- Publication type
Article
- DOI
10.1159/000487637