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- Title
Italian Real-Life Experience on the Use of Mogamulizumab in Patients with Cutaneous T-Cell Lymphomas.
- Authors
Caruso, Laura; Castellino, Alessia; Dessì, Daniela; Flenghi, Leonardo; Giordano, Antonio; Ibatici, Adalberto; Massone, Cesare; Pileri, Alessandro; Proietti, Ilaria; Pupo, Livio; Quaglino, Pietro; Rupoli, Serena; Zinzani, Pier Luigi
- Abstract
Mycosis fungoides and Sèzary syndrome are the most studied subtypes common cutaneous T-cell lymphomas. The current treatment objective is to improve the clinical manifestations of the disease in the affected areas, to relieve symptoms and to halt disease progression. Patients with early-stage mycosis fungoides are usually managed with skin-directed therapies, whereas patients with resistant or advanced-stage mycosis fungoides or Sèzary syndrome often require systemic drugs. Over the last decade, new drugs have been developed, increasing the breadth of treatment options for cutaneous T-cell lymphomas patients. Mogamulizumab is a first-in-class defucosylated humanized IgG1 κ monoclonal antibody, which exerts its anti-tumour action by selectively binding to C-C chemokine receptor 4 and increasing antibody-dependent cellular cytotoxicity activity against malignant T-cells. Several clinical trials showed that mogamulizumab is able to effectively control the cutaneous T-cell lymphomas in each site (skin, blood, lymph nodes and viscera), improving patients' symptoms, function and overall quality of life with a manageable safety profile. In this report, we discuss 12 cases of patients with mycosis fungoides or Sèzary syndrome successfully treated with mogamulizumab in real-life clinical practice in Italy.
- Subjects
ITALY; SEZARY syndrome; ANTIBODY-dependent cell cytotoxicity; MYCOSIS fungoides; T cells; LYMPHOMAS; SYMPTOMS
- Publication
Cancer Management & Research, 2022, Vol 14, p3205
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S377015