We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prognostic value of tumor-associated macrophages in pancreatic cancer: a meta-analysis.
- Authors
Yu, Min; Guan, Renguo; Hong, Weifeng; Zhou, Yu; Lin, Ye; Jin, Haosheng; Hou, Baohua; Jian, Zhixiang
- Abstract
abstracted data. Results: A total of 13 studies with 1699 patients were pooled in the analysis to evaluate prognostic value of TAMs in pancreatic cancer. The pooled HRs demonstrated CD68+ TAMs correlated with worse overall survival (OS) in pancreatic cancer patients (HR =1.41, 95% CI =1.05–1.90, random effects model, I2,=82.5%, P=0.021). And high generalized M2-TAMs density was significantly associated with poor OS (HR =1.95, 95% CI =1.63–2.33, random effects model, I2,=59.2%, P=0.000) and disease-free survival (HR =1.83, 95% CI =1.43–2.36, fixed effects model, I2,=0.00%, P=0.000). Pooled analysis showed no significant correlation between elevated TAMs infiltration and lymph node metastasis, tumor stage, histological grade, sex, or tumor location. Conclusion: The density of TAMs has an impact on the overall survival of pancreatic cancer patients. M2-TAMs can be recognized as a prognostic indicator in pancreatic cancer, which may serve as a potential therapeutic target in the treatment of pancreatic cancer.
- Subjects
PANCREATIC cancer; RANDOM effects model; PANCREATIC tumors; MACROPHAGES; PROGRESSION-free survival
- Publication
Cancer Management & Research, 2019, Vol 11, p4041
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S196951