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- Title
The relationship of the histologic grade at the deep invasive front and the expression of Ki-67 antigen and p53 protein in oral squamous cell carcinoma.
- Authors
Kurokawa, Hideo; Zhang, Min; Matsumoto, Shinobu; Yamashita, Yoshihiro; Tanaka, Toshiko; Tomoyose, Taiki; Takano, Hirofumi; Funaki, Katsuyuki; Fukuyama, Hiroshi; Takahashi, Tetsu; Sakoda, Sumio
- Abstract
Background: Although many histopathologic characteristics of oral squamous cell carcinoma (O-SCC) have been identified as prognostic factors, accurate, and unequivocal factors have not been clearly identified. The purpose of this study was to evaluate a potential association between the histologic grade of malignancy at the deep invasive front and the expression of Ki-67 antigen and p53 protein in O-SCC. Methods: The expression of Ki-67 antigen and p53 at the invasive tumor front area of O-SCC was examined by immunohistochemistry of archived tissue from 62 cases. The mean age of patients was 60.7 years (range: 37–89) and the male–female ratio was 1.6:1 (38 men, 24 women). There were 20, 17, 14, and 11 cases classified as stage I to stage IV, respectively. The correlation between the intensity of immunostaining for Ki-67 antigen and p53 and the histologic grade of malignancy at the deep invasive front (invasive front grade, IFG) was analyzed. The expression of Ki-67 antigen and p53 in normal oral epithelia (10 cases) was also investigated. Results: The mean Ki-67 labeling index (LI) in the O-SCC samples was 32.8 ± 12.0% ( n = 62). The mean total score of IFG (IFG score) was 9.1 ± 2.7 points ( n = 62). There was a significant linear correlation between the IFG score and the Ki-67 antigen ( γ = 0.651, R2 = 0.596, P < 0.0001). Of 50 tumors examined, 27 (54.0%) exhibited p53-positive nuclear immunostaining. The staining patterns for Ki-67 antigen and p53 were similar. Both Ki-67-LI and p53-positive status were significantly correlated with the IFG scores. Conclusion: The findings of this study demonstrate that overexpression of Ki-67 antigen and p53 at the deep tumor invasive front of O-SCC is associated with histologic grade of malignancy.
- Subjects
ORAL cancer; ANTIGENS; SQUAMOUS cell carcinoma; P53 protein; CANCER; IMMUNOHISTOCHEMISTRY
- Publication
Journal of Oral Pathology & Medicine, 2005, Vol 34, Issue 10, p602
- ISSN
0904-2512
- Publication type
Article
- DOI
10.1111/j.1600-0714.2005.00358.x