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- Title
Cu/graphene oxide composited coatings for preventing clinical implant bacterial infections: an antibacterial mechanism study.
- Authors
Zhao, C. H.; Yang, Y. Q.; Yang, H. L.; Tan, J. M.; Gong, R. H.; Yang, Y. X.; Zhang, X. P.
- Abstract
Recently, graphene oxide (GO) based materials have shown great potential in the treatment of implant bacterial infections due to its inherent antibacterial activity. However, the effect of GO-based materials on biological systems particularly the antibacterial mechanisms is still not clear. In this study, GO, NaBH4 treated GO (GO-Y), copper decorated GO (GO-Cu, GO-Cu-GO) composited coatings were prepared on the surface of silicon dioxide (SiO2) substrate by spin-coating and chemical in-situ formation. The growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) on GO-Y, GO-Cu, and GO-Cu-GO were significantly inhibited, especially on GO-Cu and GO-Cu-GO coatings. The implied antibacterial mechanism of GO-Cu-Cu coatings was further studied and discussed. The enhanced antibacterial performance of GO-Cu-GO coatings has significant potential application in preventing clinical implant bacterial infections. Moreover, the systematic study of various antibacterial effects also enriches our knowledge of the possible antibacterial mechanisms of graphene-based materials.
- Subjects
GRAPHENE oxide; BACTERIAL diseases; OXIDE coating; COPPER; ESCHERICHIA coli
- Publication
Digest Journal of Nanomaterials & Biostructures (DJNB), 2023, Vol 18, Issue 2, p657
- ISSN
1842-3582
- Publication type
Article
- DOI
10.15251/DJNB.2023.182.657