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- Title
Efecto analgésico postoperatorio con microdosis única de morfi na intratecal versus ketorolaco intravenoso en cirugía ginecológica.
- Authors
Gallegos-Allier, María Mónica; Santacruz, Lourdes; Lomelí, Joel
- Abstract
Background: Morphine --the prototype of opioid agonists-- is the most effective drug for the treatment of acute and chronic pain. Postoperative pain is one of the three leading causes of prolonged hospitalization. Patients and methods: This is double-blind, randomized controlled trial comparing the efficacy of a combination of intrathecal morphine (1 µg/kg) plus intravenously ketorolac versus intravenous ketorolac only (90 mg/day), in patients undergoing gynecologic surgery and combined spinal-epidural anesthesia by Visual Analogue Scale, at 6, 12 and 24 h after surgery. To statistical analysis, association was assessed with Χ² Pearson test; Mann Whitney and t Student test to difference between groups. Results: 97 females (mean age 41.75 ± 8.48) were included in the study. 49 were randomized to active treatment and 48 to control treatment. Mean Visual Analogue Scale in the morphine group was 1.27 (± 1.25) versus 4.08 (± 2.05) in the ketorolac group (p < 0.001). Conclusion: Adding intrathecal morphine to the IV ketorolac treatment reduces the intensity of postoperative pain, morphine requirements and opioidrelated side effects in the early postoperative period.
- Subjects
MEDICAL research; POSTOPERATIVE pain treatment; CLINICAL drug trials; SPINAL anesthesia; MORPHINE; DRUG therapy
- Publication
Revista Mexicana de Anestesiología, 2012, Vol 35, Issue 1, p15
- ISSN
0484-7903
- Publication type
Article