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- Title
Pharmacodynamic Study of FS-0311: A Novel Highly Potent, Selective Acetylcholinesterase Inhibitor.
- Authors
Zhi Fei Wang; Jin Yan; Yan Fu; Xi Can Tang; Song Feng; Xu Chang He; Dong Lu Bai
- Abstract
(1) This study was to evaluate the anti-cholinesterase (ChE), cognition enhancing and neuroprotective effects of FS-0311, a bis-huperzine B derivative. (2) ChE activity was evaluated using a spectrophotometric method. Cognitive deficits in mice were induced by scopolamine or transient brain ischemia and reperfusion. Water maze was used to detect the cognitive performance. PC12 cell injury was induced by β-amyloid 25-35 (Aβ25-35), oxygen-glucose deprivation (OGD), or staurosporine treatment. (3) FS-0311 was a potent, highly specific inhibitor of acetylcholinesterase (AChE). FS-0311 bound to AChE in a reversible manner, causing linear mixed-type inhibition. FS-0311 had a high oral bioavailability and a long duration of AChE inhibitory action in vivo. FS-0311 was found to antagonize cognitive deficits induced by scopolamine or transient brain ischemia and reperfusion in a water maze task. FS-0311 possessed the ability to protect PC12 cells against Aβ25-35 peptide toxicity, OGD insult and staurosporine-induced apoptosis. The neuroprotective effects of FS-0311 appeared to reflect an attenuation of oxidative stress. (4) With the profile of anti-ChE and neuroprotective activities, FS-0311 might be a promising candidate in neurodegenerative diseases, such as Alzheimer's disease and Vascular dementia.
- Publication
Cellular & Molecular Neurobiology, 2008, Vol 28, Issue 2, p245
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-007-9199-0