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- Title
A novel eudesmol derivative from the leaf essential oil of Guatteria friesiana (Annonaceae) and evaluation of the antinociceptive activity.
- Authors
Costa, Emmanoel V.; Alencar Menezes, Leociley R.; Dutra, Lívia M.; Pinheiro, Maria Lúcia B.; Lavor, Érica M.; Silva, Mariana G.; Alves, Cristiane dos S. C.; Almeida, Jackson R. G. S.; da Silva, Felipe Moura A.; Koolen, Hector H. F.; Barison, Andersson
- Abstract
In the present study, it was evaluated the chemical composition and the antinociceptive activity of the essential oil obtained from the leaves of Guatteria friesiana. Seven compounds corresponding to 96.2% of the crude essential oil were identified. The main components identified were the mixture of β-eudesmol and α-eudesmol (58.1%), and γ-eudesmol (16.8%). A new α-eudesmol derivative, named 5-hydroxy-α-eudesmol, was isolated together with the known compounds β-eudesmol and a mixture of α-eudesmol, β-eudesmol and γ-eudesmol of the essential oil. The chemical structures were determined by 1D and 2D NMR, and MS experiments. Essential oil has significant antinociceptive properties, which are related probably with the involvement of the opioid receptors and K+-ATP channels.
- Subjects
ESSENTIAL oils; OPIOID receptors; ANNONACEAE; CHEMICAL structure; PURINERGIC receptors; OPIOID peptides
- Publication
Zeitschrift für Naturforschung. Section C: A Journal of Biosciences, 2023, Vol 78, Issue 5/6, p169
- ISSN
0939-5075
- Publication type
Article
- DOI
10.1515/znc-2022-0059