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- Title
Transient Increase of Pre-existing Anti-IFN-α2 Antibodies Induced by SARS-CoV-2 Infection.
- Authors
Steels, Sophie; Van Elslande, Jan; Leuven COVID-Study Group; Cockx, Maaike; Frans, Glynis; Imbrechts, Maya; Dillaerts, Doreen; Meyts, Isabelle; Geukens, Nick; Wauters, Els; Vermeersch, Pieter; Wauters, Joost; De Munter, Paul; Bossuyt, Xavier
- Abstract
In four [[1]] and two [[2]] COVID-19 patients for whom pre-COVID-19 samples were available, autoantibodies against IFN- 2 and/or IFN- were present before SARS-CoV-2 infection. In conclusion, our findings indicate that SARS-CoV-2 infection can enhance pre-existing (neutralizing) anti-IFN- 2 antibodies and, albeit to a lesser extent, induce anti-IFN- 2 antibodies in a patient without pre-existing antibodies. It is, however, unknown whether SARS-CoV-2 infection enhances antibody formation to type I IFNs in patients with pre-existing antibodies or might even trigger antibody formation in patients without pre-existing antibodies. In one of these patients (case 9) a transient increase in anti-IFN- 2 antibody levels was observed upon SARS-CoV-2 infection, whereas in the other patient (case 10), antibody levels remained high over a long period (11 months).
- Subjects
SARS-CoV-2; MYASTHENIA gravis; CHRONIC active hepatitis; IMMUNOGLOBULINS
- Publication
Journal of Clinical Immunology, 2022, Vol 42, Issue 4, p742
- ISSN
0271-9142
- Publication type
Letter
- DOI
10.1007/s10875-022-01235-3