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- Title
I--Region--coded Products Expressed on Both Macrophages and Thymus Epithelium Influence T--Cell Activities.
- Authors
Smith, F. I.; Mottram, P. L.; Miller, J. F. A. P.
- Abstract
I-region-coded products expressed on the surface of both macrophages (Mph) and thymus epithelium were shown to restrict T-cell activities at the level of antigen recognition and determination of the T-cell repertoire. Thus keyhole limpet haemocyanin (KLH)-pulsed Mph could elicit a delayed-type hypersensitivity response in a KLH-sensitized mouse only when the Mph and the sensitized mouse were compatible at the I-A region of the major histocompatibility complex. Also, experiments with thymus-grafted chimaeras showed that I-region compatibility between the thymus of the cell donor and the reticuloendothelial system of the recipient was essential for successful transfer of the DTH reaction. Thus, F1 T cells derived from stem cells differentiating in a P1 thymus graft, where F1 parents (P1 and P2) differed only at defined regions of the H-2 complex, could always transfer sensitivity to P1 mice. However, successful transfer to P2 mice was possible only if P1 and P2 were H-21-compatible.
- Subjects
MACROPHAGES; EPITHELIUM; ANTIGENS; T cells; THYMUS; LYMPHOID tissue
- Publication
Scandinavian Journal of Immunology, 1979, Vol 10, Issue 4, p343
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1979.tb01361.x