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- Title
Radionecrosis or tumor recurrence after radiation of laryngeal and hypopharyngeal carcinomas
- Authors
Zbären, Peter; Caversaccio, Marco; Thoeny, Harriet C.; Nuyens, Michel; Curschmann, Jürgen; Stauffer, Edouard
- Abstract
Objective: To analyze the incidence and diagnostic difficulties of radionecrosis vs tumor recurrence of laryngeal and hypopharyngeal carcinomas. Study design and setting: Retrospective study on 341 patients treated by radiation alone or radiochemotherapy. The clinicopathologic findings, work-up, treatment, and follow-up of 20 patients with symptoms suggestive but negative for tumor recurrence on initial imaging studies and endoscopy were analyzed. Results: The incidence of chondroradionecrosis in 341 irradiated patients was 5%. Ten of 20 patients initially negative for tumor recurrence were treated by total laryngectomy; in all laryngectomy specimens, chondroradionecrosis was present, in six specimens associated with tumor recurrence. Ten patients were treated by tracheotomy and tumor recurrence was detected in one patient during follow-up. Conclusion: Chondroradionecrosis is a relatively rare treatment complication. Typical imaging findings suggestive of radionecrosis are often missing. Tumor recurrence may be present beneath an intact mucosa and missed by endoscopy.
- Subjects
CANCER patients; TUMORS; ENDOSCOPY; LARYNGECTOMY
- Publication
Otolaryngology-Head & Neck Surgery, 2006, Vol 135, Issue 6, p838
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2006.06.1264