We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Manufacturing of human placenta-derived mesenchymal stem cells for clinical trials.
- Authors
Brooke, Gary; Rossetti, Tony; Pelekanos, Rebecca; Ilic, Nina; Murray, Patricia; Hancock, Sonia; Antonenas, Vicki; Huang, Gillian; Gottlieb, David; Bradstock, Ken; Atkinson, Kerry
- Abstract
Mesenchymal stem cells (MSC) are being used increasingly in clinical trials for a range of regenerative and inflammatory diseases. Bone marrow is the traditional source but is relatively inaccessible in large volume. MSC have now been derived from tissues other than bone marrow including placenta and adipose tissue. We have used placenta obtained after delivery as a source of MSC and have been unable to detect any marked differences from marrow-derived MSC in terms of cell surface phenotype, chemokine receptor display, mesodermal differentiation capacity or immunosuppressive ability. This report described our manufacturing process for isolating and expanding placenta-derived human MSC and their safe infusion into the first patient in a clinical trial program of human placenta-derived MSC.
- Subjects
STEM cell treatment; MESENCHYME; CLINICAL trials; INFLAMMATION treatment; BONE marrow; PLACENTA; ADIPOSE tissues
- Publication
British Journal of Haematology, 2009, Vol 144, Issue 4, p571
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2008.07492.x