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- Title
Letter to the Editor From A.H. Jan Danser and Ingrid M. Garrelds: The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone–Renin Ratio Calculations.
- Authors
Danser, A H Jan; Garrelds, Ingrid M
- Abstract
The article discusses the phenomenon of cryoactivation, which refers to a cold-induced change in prorenin, the inactive precursor of renin. The authors explain that storing plasma samples at low temperatures for a long time can lead to the inactivation of serine protease inhibitors, resulting in the generation of kallikrein, which can cleave the prosegment of prorenin. The authors argue that storing samples at -20 °C is sufficient and that there is no advantage to storing them at -70 °C. They also mention that renin inhibitors can bind to the active site of prorenin, leading to overestimation of renin levels in certain assays.
- Subjects
LOW temperature plasmas; RENIN inhibitors; SERINE proteinases; SECRETORY granules; RENIN
- Publication
Journal of Clinical Endocrinology & Metabolism, 2024, Vol 109, Issue 9, pe1806
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgae243