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- Title
A randomized controlled study of immediate versus delayed umbilical cord clamping in infants born by elective caesarean section.
- Authors
De Bernardo, Giuseppe; Giordano, Maurizio; De Santis, Rita; Castelli, Paola; Sordino, Desiree; Trevisanuto, Daniele; Buonocore, Giuseppe; Perrone, Serafina
- Abstract
Background: Delayed umbilical cord clamping is associated with greater haemoglobin concentration and iron storage between 3 and 6 months of life and with less need of blood transfusion and lower incidence of neonatal hypotension compared to early umbilical cord clamping. Methods: The aim was to test the hypothesis that delayed cord clamping is better than early cord clamping in term infants born by elective caesarean section. Group A was subjected to immediate cord clamping while in the Group B, the umbilical cord was clamped 1 min after birth. Primary aim was revealed the difference in pre-ductal saturation between two groups while secondary aim was investigating the difference in HR, Ht, bilirubin and glycaemia. Pre-ductal SpO2 and HR were recorded at 5 and 10 min after birth, T was analysed 10 min after birth, glycaemia was revealed at 120 min while Ht and bilirubin were collected at 72 h. Results: 132 newborns were enrolled in the study and allocated in ratio 1:1 to group A or B. Delayed cord clamping did not improve SpO2, HR and T values compared to immediate cord clamping (p > 0,05). However, Group B showed greater haematocrit and bilirubin values at 72 h compared to Group A (56,71 ± 6663 vs 51,56 ± 6929; p < 0,05 and 8,54 ± 2,90 vs 7,06 ± 2,76; p < 0,05). Glycaemia value did not differ between two groups (p > 0,05). Conclusions: Group B did not reveal any differences in SpO2, HR, T and glycaemia compared to Group A. Group B showed greater values of haematocrit and bilirubin but without need of phototherapy. Trial registration: Umbilical Cord Clamping: What Are the Benefits; NCT03878602. Registered 18 March 2019 retrospectively registered.
- Subjects
BILIRUBIN; BLOOD sugar; BODY temperature; CESAREAN section; HEART beat; HEMATOCRIT; HEMOGLOBINS; IRON; OXYGEN in the body; STATISTICAL sampling; TIME; RANDOMIZED controlled trials; TREATMENT effectiveness; UMBILICAL cord clamping; EVALUATION; CHILDREN
- Publication
Italian Journal of Pediatrics, 2020, Vol 46, Issue 1, p1
- ISSN
1720-8424
- Publication type
Article
- DOI
10.1186/s13052-020-00835-2